ABSTRACT
Abstract Objective This investigation describes the effects of 5% sodium fluoride varnish and 38% silver diamine fluoride on demineralization protection of human enamel lesions of three different severities after a secondary acid challenge. Study design Specimens underwent color and enamel surface microhardness change measurements after demineralization and treatment events. Transverse microradiography was conducted following the secondary demineralization. Results After treatments, enamel surface microhardness change showed that 24-hour lesions treated with fluoride varnish had less rehardening than 24-hour lesions treated with silver diamine fluoride (p<0.05), whereas 144-hour lesions from both treatment groups showed a beneficial decrease in surface microhardness change that was markedly better in samples treated with silver diamine fluoride (p<0.05). After the secondary demineralization, 24- and 144-hour lesions treated with silver diamine fluoride showed a sustained beneficial decrease in enamel surface microhardness change when compared to fluoride varnish-treated samples of the corresponding lesion severity (p<0.05). Transverse microradiography showed no difference between fluoride varnish- and silver diamine fluoride-treated samples of any corresponding lesion severity, indicating that remineralization in both fluoride varnish- and silver diamine fluoride-treated samples was proportional to each other after a secondary acid challenge. Conclusions Using silver diamine fluoride may have comparable benefits to fluoride varnish in mineral loss prevention.
ABSTRACT
The purpose of this study was to assess the correlation between integrated mineral loss (volume % mineral×µm, ΔZ(TMR)) determined using transverse microradiography (TMR) and integrated reflectivity (dB×µm, ΔR(OCT)) determined using optical coherence tomography (OCT) for detecting early dental caries with lesion depth more than 200 µm. Sixty tooth specimens were made from sound bovine teeth. They were immersed in a demineralized solution for 20, 30, and 40 days. The ΔR(OCT) was obtained from the cross-sectional OCT image. The ΔZ(TMR) was obtained from the TMR image. The correlation between ΔR(OCT) and ΔZ(TMR) was examined using Pearson correlation. The Bland-Altman plot was constructed using the ΔR(OCT) and ΔZ(TMR) values. A significant correlation between ΔR(OCT) and ΔZ(TMR) was confirmed (r=0.491, p=0.003). Moreover, most of the difference between ΔR(OCT) and ΔZ(TMR) was included in the error section of the Bland-Altman plot. Therefore, OCT could be used as a substitute for TMR when analyzing mineral loss in early dental caries.